Highly sensitive amyloid detection enabled by thioflavin T dimers.
نویسندگان
چکیده
Fluorescent molecules that specifically target amyloid structures are highly desirable for amyloid research. Herein, we show a dimeric design of thioflavin T improves its binding affinity to Abeta amyloid by up to 70 fold, while not sacrificing the specificity and the "light-up" feature upon amyloid binding.
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ورودعنوان ژورنال:
- Molecular bioSystems
دوره 6 10 شماره
صفحات -
تاریخ انتشار 2010